Incumbent Republican Joe Wilson holds a clear edge over Democratic challenger Zyon Khalifa in South Carolina’s 2nd District, with forecasts projecting a Republican margin near 10 points on November 3. Trader pricing across margin buckets reflects uncertainty over turnout and national headwinds that could compress or expand the final spread. The district’s shift from a 19-point Republican win in 2024 to a narrower projected gap stems from broader midterm dynamics favoring Democrats in suburban areas, though the seat’s underlying partisan lean and Wilson’s long incumbency continue to anchor expectations. Late campaign events, voter mobilization efforts, or shifts in the generic ballot could alter the outcome within the resolution window.